Insider filing report for Changes in Beneficial Ownership
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- Schedule 13G is a shorter version of Schedule 13D with fewer reporting requirements.
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
SCHEDULE 13D
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULE 13d-l(a) AND AMENDMENTS THERETO FILED PURSUANT
TO RULE 13d-2(a)
(Amendment No. 3)*
Prelude Therapeutics Incorporated
(Name of Issuer)
Common stock, par value $0.0001 per share
(Title of Class of Securities)
74065P101
(CUSIP number)
Alexandra A. Toohey
Chief Financial Officer
Baker Bros. Advisors LP
860 Washington Street, 3rd Floor
New York, NY 10014
(212) 339-5690
(Name, address and telephone number of person authorized to receive notices and communications)
December 11, 2023
(Date of event which requires filing of this statement)
If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box ¨.
(Continued on the following pages)
(Page 1 of 10 Pages)
________________________________
*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.
| CUSIP No. 74065P101 | Page 2 of 10 Pages |
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1. |
NAMES OF REPORTING PERSONS Baker Bros. Advisors LP | ||
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2. |
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) ¨ (b) ¨ | ||
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3. |
SEC USE ONLY | ||
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4. |
SOURCE OF FUNDS* OO | ||
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5. |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) o | ||
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6. |
CITIZENSHIP OR PLACE OF ORGANIZATION Delaware | ||
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NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7. |
SOLE VOTING POWER: 10,222,968 (1) | |
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8. |
SHARED VOTING POWER: 0 | ||
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9. |
SOLE DISPOSITIVE POWER: 10,222,968 (1) | ||
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10. |
SHARED DISPOSITIVE POWER: 0 | ||
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11. |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 10,222,968 (1) | ||
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12. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* ¨ | ||
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13. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 24.3% (1)(2) | ||
|
14. |
TYPE OF REPORTING PERSON* IA, PN | ||
| (1) | Includes 99,144 shares of voting common stock (“Common Stock”) of Prelude Therapeutics Incorporated (the “Issuer”) underlying 99,144 options to purchase Common Stock of the Issuer (“Stock Options”) and 5,188 shares of Common Stock directly held by Baker Bros. Advisors LP (the “Adviser”) from Exercised Stock Options (as defined in Item 5). |
| (2) | Based on 41,981,234 shares of Common Stock outstanding as of December 8, 2023 as reported in the Securities Purchase Agreement (as defined in Item 4 and filed in Exhibit 99.1 of this Schedule 13D). |
| CUSIP No. 74065P101 | Page 3 of 10 Pages |
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1. |
NAMES OF REPORTING PERSONS Baker Bros. Advisors (GP) LLC | ||
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2. |
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) ¨ (b) ¨ | ||
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3. |
SEC USE ONLY | ||
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4. |
SOURCE OF FUNDS* OO | ||
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5. |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) o | ||
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6. |
CITIZENSHIP OR PLACE OF ORGANIZATION Delaware | ||
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NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7. |
SOLE VOTING POWER: 10,222,968 (1) | |
|
8. |
SHARED VOTING POWER: 0 | ||
|
9. |
SOLE DISPOSITIVE POWER: 10,222,968 (1) | ||
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10. |
SHARED DISPOSITIVE POWER: 0 | ||
|
11. |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 10,222,968 (1) | ||
|
12. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* ¨ | ||
|
13. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 24.3% (1)(2) | ||
|
14. |
TYPE OF REPORTING PERSON* HC, OO | ||
| (1) | Includes 99,144 shares of Common Stock of the Issuer underlying 99,144 Stock Options and 5,188 shares of Common Stock directly held by the Adviser from Exercised Stock Options (as defined in Item 5). |
| (2) | Based on 41,981,234 shares of Common Stock outstanding as of December 8, 2023 as reported in the Securities Purchase Agreement (as defined in Item 4 and filed in Exhibit 99.1 of this Schedule 13D). |
| CUSIP No. 74065P101 | Page 4 of 10 Pages |
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1.
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NAMES OF REPORTING PERSONS Felix J. Baker | ||
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2.
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) ¨ (b) ¨ | ||
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3. |
SEC USE ONLY | ||
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4.
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SOURCE OF FUNDS* OO | ||
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5. |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) o | ||
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6.
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CITIZENSHIP OR PLACE OF ORGANIZATION United States | ||
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NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7. |
SOLE VOTING POWER: 10,222,968 (1) | |
|
8. |
SHARED VOTING POWER: | ||
|
9. |
SOLE DISPOSITIVE POWER: 10,222,968 (1) | ||
|
10. |
SHARED DISPOSITIVE POWER: | ||
|
11. |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 10,222,968 (1) | ||
|
12. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* ¨ | ||
|
13. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 24.3% (1)(2) | ||
|
14.
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TYPE OF REPORTING PERSON* IN, HC | ||
| (1) | Includes 99,144 shares of Common Stock of the Issuer underlying 99,144 Stock Options and 5,188 shares of Common Stock directly held by the Adviser from Exercised Stock Options (as defined in Item 5). |
| (2) | Based on 41,981,234 shares of Common Stock outstanding as of December 8, 2023 as reported in the Securities Purchase Agreement (as defined in Item 4 and filed in Exhibit 99.1 of this Schedule 13D). |
| CUSIP No. 74065P101 | Page 5 of 10 Pages |
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1.
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NAMES OF REPORTING PERSONS Julian C. Baker | ||
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2.
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) ¨ (b) ¨ | ||
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3. |
SEC USE ONLY | ||
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4.
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SOURCE OF FUNDS* OO | ||
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5. |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) o | ||
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6.
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CITIZENSHIP OR PLACE OF ORGANIZATION United States | ||
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NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7. |
SOLE VOTING POWER: 10,222,968 (1) | |
|
8. |
SHARED VOTING POWER | ||
|
9. |
SOLE DISPOSITIVE POWER: 10,222,968 (1) | ||
|
10. |
SHARED DISPOSITIVE POWER: | ||
|
11. |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 10,222,968 (1) | ||
|
12. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* ¨ | ||
|
13.
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 24.3% (1)(2) | ||
|
14.
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TYPE OF REPORTING PERSON* IN, HC | ||
| (1) | Includes 99,144 shares of Common Stock of the Issuer underlying 99,144 Stock Options and 5,188 shares of Common Stock directly held by the Adviser from Exercised Stock Options (as defined in Item 5). |
| (2) | Based on 41,981,234 shares of Common Stock outstanding as of December 8, 2023 as reported in the Securities Purchase Agreement (as defined in Item 4 and filed in Exhibit 99.1 of this Schedule 13D). |
Amendment No. 3 to Schedule 13D
This Amendment No. 3 to Schedule 13D amends and supplements the previously filed Schedules 13D filed by Baker Bros. Advisors LP (the “Adviser”), Baker Bros. Advisors (GP) LLC (the “Adviser GP”), Julian C. Baker, and Felix J. Baker (collectively the “Reporting Persons”). Except as supplemented herein, such statements, as heretofore amended and supplemented, remain in full force and effect.
The Adviser GP is the sole general partner of the Adviser. Pursuant to the management agreements, as amended, among the Adviser, Baker Brothers Life Sciences, L.P. (“Life Sciences”) and 667, L.P. (“667”, and together with Life Sciences, the “Funds”), and their respective general partners, the Funds’ respective general partners relinquished to the Adviser all discretion and authority with respect to the investment and voting power over securities held by the Funds, and thus the Adviser has complete and unlimited discretion and authority with respect to the Funds’ investments and voting power over investments.
All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D, as amended. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable.
| Item 3. | Source and Amount of Funds or Other Consideration |
Item 3 of this Schedule 13D is supplemented and superseded, as the case may be, as follows:
The disclosure in Item 4 below is incorporated herein by reference.
| Item 4. | Purpose of the Transaction |
Item 4 of this Schedule 13D is supplemented and superseded, as the case may be, as follows:
The disclosure in Item 6 is incorporated herein by reference.
On December 11, 2023, Prelude Therapeutics Incorporated (the “Issuer”) entered into a securities purchase agreement (the “Securities Purchase Agreement”) with the Funds, providing for a private placement (the “Offering”) of 7,936,759 prefunded warrants of the Issuer to purchase up to 7,936,759 shares of the Issuer’s Common Stock (the “Prefunded Warrants”), at a price of $3.1499 per warrant with an exercise price of $0.0001 per share. The Offering closed on December 13, 2023.
Pursuant to the Offering, 667 and Life Sciences purchased 593,452 and 7,343,307 Prefunded Warrants, respectively, totaling 7,936,759 Prefunded Warrants in the aggregate. Each of the Funds purchased the Prefunded Warrants with its working capital.
The Prefunded Warrants are exercisable on a 1-for-1 basis at any time at the election of the holder into shares of Common Stock subject to beneficial ownership limitations as described below. The Prefunded Warrants are only exercisable to the extent that after giving effect to such exercise the holders thereof, together with their affiliates and any members of a Section 13(d) group with such holders, would beneficially own, for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended, no more than 4.99% of the outstanding shares of Common Stock (the “Maximum Percentage”). By written notice to the Issuer, the Funds may from time to time increase or decrease the Maximum Percentage applicable to that Fund to any other percentage not in excess of 19.99%. Any such increase will not be effective until the 61st day after such notice is delivered to the Issuer. As a result of this restriction, the number of shares that may be issued upon exercise of the Prefunded Warrants by the above holders may change depending upon changes in the number of outstanding shares of Common Stock. The Prefunded Warrants are not currently exercisable due to the effect of the Maximum Percentage.
The Funds hold securities of the Issuer for investment purposes. The Reporting Persons or their affiliates may purchase additional securities or dispose of securities in varying amounts and at varying times depending upon the Reporting Persons’ continuing assessments of pertinent factors, including the availability of shares of Common Stock or other securities for purchase at particular price levels, the business prospects of the Issuer, other business investment opportunities, economic conditions, stock market conditions, money market conditions, the attitudes and actions of the board of directors of the Issuer (the “Board”) and management of the Issuer, the availability and nature of opportunities to dispose of securities of the Issuer and other plans and requirements of the particular entities. The Reporting Persons may discuss items of mutual interest with the Issuer’s management, other members of the Board and other investors, which could include items in subparagraphs (a) through (j) of Item 4 Schedule 13D.
Depending upon their assessments of the above factors, the Reporting Persons or their affiliates may change their present intentions as stated above and they may assess whether to make suggestions to the management of the Issuer regarding financing, and whether to acquire additional securities of the Issuer (by means of open market purchases, privately negotiated purchases, conversion of some or all of the Non-Voting Common Stock (defined in Item 5), exercise of some of all of the Prefunded Warrants, exercise of some or all of the Stock Options (defined in Item 5), or otherwise) or to dispose of some or all of the securities of the Issuer under their control.
Except as otherwise disclosed herein, at the present time, the Reporting Persons do not have any plans or proposals with respect to any extraordinary corporate transaction involving the Issuer including, without limitation, those matters described in subparagraphs (a) through (j) of Item 4 of Schedule 13D.
| Item 5. | Interest in Securities of the Issuer |
(a) and (b) Items 7 through 11 and 13 of each of the cover pages of this Amendment No. 3 are incorporated herein by reference.
The information set forth in Item 4 is hereby incorporated by reference into this Item 5.
Set forth below is the aggregate number of shares of Common Stock directly held by each of the Funds, which may be deemed to be indirectly beneficially owned by the Reporting Persons, as well as the shares of Common Stock that may be acquired upon conversion of Non-Voting Common Stock or exercise of Prefunded Warrants by the Funds, subject to, respectively, the Beneficial Ownership Limitation (as defined below) and the Maximum Percentage.
| Holder | Common Stock | Non-Voting Common Stock | Prefunded Warrants | |||||||||
| 667, L.P. | 870,873 | 630,658 | 1,563,672 | |||||||||
| Baker Brothers Life Sciences, L.P. | 9,247,763 | 6,539,415 | 17,968,343 | |||||||||
| Total | 10,118,636 | 7,170,073 | 19,532,015 | |||||||||
Shares of non-voting common stock of the Issuer (“Non-Voting Common Stock”) are convertible on a 1-for-1 basis at any time at the election of the holder into shares of Common Stock subject to beneficial ownership limitations as described below. The shares of Non-Voting Common Stock are only convertible to the extent that after giving effect to such conversion the holders thereof, together with their affiliates and any members of a Section 13(d) group with such holders, would beneficially own, for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended, no more than 9.99% of the outstanding shares of Common Stock (the “Beneficial Ownership Limitation”). By written notice to the Issuer, the Funds may from time to time increase or decrease the Beneficial Ownership Limitation applicable to that Fund to any other percentage not in excess of 19.99%. Any such change will not be effective until the 61st day after such notice is delivered to the Issuer. As a result of this restriction, the number of shares that may be issued upon conversion of the Non-Voting Common Stock by the above holders may change depending upon changes in the number of outstanding shares of Common Stock. The Non-Voting Common Stock is not currently convertible due to the effect of the Beneficial Ownership Limitation.
The Adviser has voting and investment power over the Common Stock, non-qualified options to purchase Common Stock (“Stock Options”), Common Stock underlying such Stock Options and Common Stock received from the exercise of Stock Options by Julian C. Baker as directors’ compensation. The Adviser GP, and Felix J. Baker and Julian C. Baker as managing members of the Adviser GP, may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the disposition of the Common Stock, Stock Options, Common Stock received from the exercise of Stock Options and Common Stock underlying such Stock Options received by Julian C. Baker received as director’s compensation.
The Adviser GP, Felix J. Baker and Julian C. Baker as managing members of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the Funds.
Dr. Kelvin M. Neu, a former full-time employee of the Adviser, holds 41,500 Stock Options, as compensation for his previous service on the Board, of which 41,500 are vested within 60 days hereof. The Stock Options held by Dr. Neu are exercisable at $12.85 per share and expire on September 1, 2030. Dr. Neu previously served, and Julian C. Baker currently serves, on the Board, each as a representative of the Funds. Vesting of the Stock Options held by Dr. Neu is subject to Julian C. Baker’s continuing service on the Board on each vesting date.
Julian C. Baker, a managing member of the Adviser GP, serves on the Board as a Class II Director and also serves on the Issuer’s compensation committee and acts as chairman of the Issuer’s nominating and governance committee. Julian C. Baker holds 23,344 Stock Options with an exercise price of $31.02 per share and an expiration date of June 18, 2031 and 34,300 Stock Options with an exercise price of $4.74 expiring on June 16, 2032. The abovementioned Stock Options held by Julian C. Baker are vested or will vest within 60 days hereof. Julian C. Baker holds 23,500 Stock Options with an exercise price of $5.56 per share and an expiration date of June 15, 2033 which vest on the earlier of June 16, 2024 or the date of the next annual general meeting of shareholders of the Issuer.
The Adviser holds 5,188 shares of Common Stock of the Issuer, as a result of the exercise of 5,188 of the Stock Options (the “Exercised Stock Options”) previously held directly by Dr. Neu. The policy of the Funds and the Adviser does not permit managing members of the Adviser GP or full-time employees of the Adviser to receive compensation for serving as directors of the Issuer, and the Funds are instead entitled to the pecuniary interest in the Exercised Stock Options. Dr. Neu, as a former full-time employee of the Adviser and former director of the Issuer, entered into a Nominee Agreement (the “Nominee Agreement”) with the Adviser on January 23, 2021. Pursuant to the Nominee Agreement, Dr. Neu agreed that, with respect to the Stock Options, the Exercised Stock Options and the Common Stock received as a result of the exercise of the Exercised Stock Options, the Adviser will have dispositive power as well as the ability to control the timing of exercise of the Exercised Stock Options and that any proceeds from the sale of the Common Stock will be remitted to the Adviser net of brokerage commissions consistent with the policies of the Adviser for current employees. Other than through their control of the Adviser, Felix J. Baker and Julian C. Baker have neither voting nor dispositive power and have no direct pecuniary interest in the Exercised Stock Options or the Common Stock.
(c) The information set forth in Items 3 and 4 is hereby incorporated by reference into this Item 5(c). Except as disclosed herein, none of the Reporting Persons or their affiliates has effected any other transactions in securities of the Issuer during the past 60 days.
(d) Certain securities of the Issuer are held directly by 667, a limited partnership the sole general partner of which is Baker Biotech Capital, L.P., a limited partnership the sole general partner of which is Baker Biotech Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of Baker Biotech Capital (GP), LLC.
Certain securities of the Issuer are held directly by Life Sciences, a limited partnership the sole general partner of which is Baker Brothers Life Sciences Capital, L.P., a limited partnership the sole general partner of which is Baker Brothers Life Sciences Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of Baker Brothers Life Sciences Capital (GP), LLC.
(e) Not applicable.
| Item 6. | Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer |
The disclosure in Item 4 is incorporated herein by reference.
Securities Purchase Agreement
On December 11, 2023, the Funds entered into the Securities Purchase Agreement with the Issuer. The Securities Purchase Agreement contains customary representations, warranties, and agreements by the Issuer and the Funds.
The foregoing description of the Securities Purchase Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Securities Purchase Agreement, which is filed as Exhibit 99.1, and incorporated herein by reference.
Amended and Restated Registration Rights Agreement
On December 11, 2023, the Issuer entered into an Amended and Restated Registration Rights Agreement (the “Amended Registration Rights Agreement”) amending and restating the Registration Rights Agreement, dated as of December 20, 2020, by and between the Funds and the Issuer. Under the Amended Registration Rights Agreement, the Issuer agreed, promptly following the closing of the Offering but no later than thirty (30) days after such closing, to prepare and file with the United States Securities & Exchange Commission a Registration Statement on Form S-3 (except if the Issuer is not then eligible to register for resale the Registrable Securities (as defined in the Amended Registration Rights Agreement) on Form S-3, in which case such registration statement shall be on another appropriate form) covering the resale of all of the shares underlying the Prefunded Warrants. On December 13, 2023, the Funds agreed to permit the Issuer to instead file the registration statement covering the resale of the shares underlying the Prefunded Warrants promptly, but no later than ten (10) days, after the Issuer files its Annual Report on Form 10-K for the year ended December 31, 2023.
The Amended Registration Rights Agreement additionally provides that if at any time the Funds demand that the Issuer register securities directly held by them for resale under the Securities Act of 1933, as amended, the Issuer will be obligated to effect such registration and granted “piggyback” registration rights relating to a registration statement that registers securities for resale on behalf of another selling stockholder. The Issuer’s registration obligations under the Amended Registration Rights Agreement cover all securities now held or later acquired by the Funds, including securities issued or issuable upon the exercise or conversion of any other securities, and will continue in effect for up to ten years as long as securities held by the Funds remain Registrable Securities, provided that Registrable Securities owned by the Funds immediately prior to the Securities Purchase Agreement shall cease to be Registrable Securities on December 20, 2030. Additionally, the Amended Registration Rights Agreement includes the Issuer’s obligation to facilitate certain underwritten public offerings of securities by the Funds in the future, including no more than an aggregate of two underwritten public offerings per calendar year and a total of no more than two total underwritten public offerings.
The foregoing description of the Amended Registration Rights Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Am ended Registration Rights Agreement, which is filed as Exhibit 99.2, and incorporated herein by reference.
| Item 7. | Material to be Filed as Exhibits |
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
December 13, 2023
|
BAKER BROS. ADVISORS LP
By: Baker Bros. Advisors (GP) LLC, its general partner | ||
| By: | /s/ Scott L. Lessing | |
Name: Scott L. Lessing Title: President | ||
| BAKER BROS. ADVISORS (GP) LLC | ||
| By: | /s/ Scott L. Lessing | |
Name: Scott L. Lessing Title: President | ||
| /s/ Julian C. Baker | |
| Julian C. Baker | |
| /s/ Felix J. Baker | |
| Felix J. Baker |