Sec Form 13G Filing - Polar Capital Holdings Plc filing for SPYRE THERAPEUTICS, INC (SYRE) - 2023-07-28

Insider filing report for Changes in Beneficial Ownership

  • Schedule 13G & 13D forms are used to report a party's ownership of stock which exceeds 5% of a company's total stock issue.
  • Schedule 13G is a shorter version of Schedule 13D with fewer reporting requirements.
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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

 

SCHEDULE 13G

 

Under the Securities Exchange Act of 1934

(Amendment No. )*



AEGLEA BIOTHERAPEUTICS, INC.

(Name of Issuer)

 

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

 

00773J103

(CUSIP Number)

 

 

July 19, 2023
(Date of Event Which Requires Filing of this Statement)

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

 

o Rule 13d-1(b)

x Rule 13d-1(c)

o Rule 13d-1(d)

 

 

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

 

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 


 
CUSIP No.  00773J103
 SCHEDULE 13G
Page 2 of 9 Pages

 

         
1
NAME OF REPORTING PERSONS
 
Polar Capital Holdings Plc
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) o
(b) o
 
3
SEC USE ONLY
 
 
4
CITIZENSHIP OR PLACE OF ORGANIZATION
 
United Kingdom
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
5
SOLE VOTING POWER
 
3,936,198
6
SHARED VOTING POWER
 
0
7
SOLE DISPOSITIVE POWER
 
3,936,198
8
SHARED DISPOSITIVE POWER
 
0
9
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 
3,936,198
10
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
 
 
o
11
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
 
5.02%
12
TYPE OF REPORTING PERSON
 
HC

 


 
CUSIP No.  00773J103
 SCHEDULE 13G
Page 3 of 9 Pages

 

         
1
NAME OF REPORTING PERSONS
 
Polar Capital LLP
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) o
(b) o
 
3
SEC USE ONLY
 
 
4
CITIZENSHIP OR PLACE OF ORGANIZATION
 
United Kingdom
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
5
SOLE VOTING POWER
 
3,936,198
6
SHARED VOTING POWER
 
0
7
SOLE DISPOSITIVE POWER
 
3,936,198
8
SHARED DISPOSITIVE POWER
 
0
9
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 
3,936,198
10
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
 
 
o
11
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
 
5.02%
12
TYPE OF REPORTING PERSON
 
IA

 


 
CUSIP No.  00773J103
 SCHEDULE 13G
Page 4 of 9 Pages

 

         
1
NAME OF REPORTING PERSONS
 
Polar Capital Funds PLC - Biotechnology Fund
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) o
(b) o
 
3
SEC USE ONLY
 
 
4
CITIZENSHIP OR PLACE OF ORGANIZATION
 
United Kingdom
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
5
SOLE VOTING POWER
 
3,936,198
6
SHARED VOTING POWER
 
0
7
SOLE DISPOSITIVE POWER
 
3,936,198
8
SHARED DISPOSITIVE POWER
 
0
9
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 
3,936,198
10
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
 
 
o
11
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
 
5.02%
12
TYPE OF REPORTING PERSON
 
OO

 


 

 

CUSIP No. 00773J103
 SCHEDULE 13G
Page 5 of 9 Pages

 

Item 1.(a) Name of Issuer

AEGLEA BIOTHERAPEUTICS, INC.

Item 1.(b) Address of Issuer’s Principal Executive Offices

805 Las Cimas Parkway, Suite 100

Austin, TX 78746

Item 2.(a) Name of Person Filing:

Polar Capital Holdings Plc

Polar Capital LLP

Polar Capital Funds PLC - Biotechnology Fund

 

Item 2.(b,) Address of Principal Business Office:

16 Palace Street

London, SW1E 5JD

 

George's Court, 54-62 Townsend Street

Dublin 2, Ireland

 

Item 2.(c) Citizenship:

United Kingdom

  

Item 2.(d) Title of Class of Securities

Common Stock, par value $0.0001 per share (the “Common Stock”)

 

Item 2.(e) CUSIP No.:

00773J103

 

CUSIP No.  00773J103
 SCHEDULE 13G
Page 6 of 9 Pages

 

 

Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

  (a) ¨ Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
 
  (b) ¨ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
 
  (c) ¨ Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
 
  (d) ¨ Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
 
  (e) o An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
 
  (f) ¨ An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);
 
  (g) o A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);
 
  (h) ¨ A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
 
  (i) ¨ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
 
  (j) o A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);
 
  (k) ¨ A group, in accordance with §240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution:                            
       

 

CUSIP No. 00773J103
 SCHEDULE 13G
Page 7 of 9 Pages

 

 

Item 4. Ownership

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1:

Polar Capital Holdings Plc

(a) Amount beneficially owned: 3,936,198

(b) Percent of class: 5.02%*

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 3,936,198

(ii) Shared power to vote or to direct the vote: 0

(iii) Sole power to dispose or to direct the disposition of: 3,936,198

(iv) Shared power to dispose or to direct the disposition of: 0

 

Polar Capital LLP

(a) Amount beneficially owned: 3,936,198

(b) Percent of class: 5.02%*

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 3,936,198

(ii) Shared power to vote or to direct the vote: 0

(iii) Sole power to dispose or to direct the disposition of: 3,936,198

(iv) Shared power to dispose or to direct the disposition of: 0 

 

Polar Capital Funds PLC - Biotechnology Fund

(a) Amount beneficially owned: 3,936,198

(b) Percent of class: 5.02%*

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 3,936,198

(ii) Shared power to vote or to direct the vote: 0

(iii) Sole power to dispose or to direct the disposition of: 3,936,198

(iv) Shared power to dispose or to direct the disposition of: 0 

 

* Based on 78,408,795 shares outstanding, based on data reported by the issuer.

Item 5. Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [ ].

Item 6. Ownership of More Than Five Percent on Behalf of Another Person

Not Applicable.

Item 7. Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company or Control Person 

Information for each Subsidiary is incorporated on the respective cover pages..

Item 8. Identification and Classification of Members of the Group

Not Applicable.

Item 9. Notice of Dissolution of Group 

Not Applicable.

Item 10. Certification

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

 

 
CUSIP No. 00773J103
 SCHEDULE 13G
Page 8 of 9 Pages

 

 

SIGNATURE

 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

 

Dated: July 28, 2023

 

 

 

POLAR CAPITAL HOLDINGS PLC

       
  By:  Nicholas Farren
   

Name: Nicholas Farren

Title: Chief Operating Officer 

       
 

POLAR CAPITAL LLP

       
  By:  Nicholas Farren
   

Name: Nicholas Farren

Title: Chief Operating Officer

       

POLAR CAPITAL FUNDS PLC - BIOTECHNOLOGY FUND

       
  By:  Nicholas Farren
   

Name: Nicholas Farren

Title: Chief Operating Officer 

       

 

 
CUSIP No. 00773J103
 SCHEDULE 13G
Page 9 of 9 Pages

 

Exhibit I

 

JOINT FILING STATEMENT

 

PURSUANT TO RULE 13d-1(k)

 

The undersigned acknowledge and agree that the foregoing statement on SCHEDULE 13G, is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on SCHEDULE 13G, shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him or it contained therein, but shall not be responsible for the completeness and accuracy of the information concerning the others, except to the extent that he or it knows or has reason to believe that such information is inaccurate.

 

Dated: July 28, 2023

 

 

 

POLAR CAPITAL HOLDINGS PLC

       
  By:  Nicholas Farren
   

Name: Nicholas Farren

Title: Chief Operating Officer 

       
 

POLAR CAPITAL LLP

       
  By:  Nicholas Farren
   

Name: Nicholas Farren

Title: Chief Operating Officer 

       

POLAR CAPITAL FUNDS PLC - BIOTECHNOLOGY FUND

       
  By:  Nicholas Farren
   

Name: Nicholas Farren

Title: Chief Operating Officer