Sec Form 13G Filing - Invus Global Management LLC filing for Silence Therapeutics plc (SLN) - 2024-11-12

Insider filing report for Changes in Beneficial Ownership

  • Schedule 13G & 13D forms are used to report a party's ownership of stock which exceeds 5% of a company's total stock issue.
  • Schedule 13G is a shorter version of Schedule 13D with fewer reporting requirements.
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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

SCHEDULE 13G

Under the Securities Exchange Act of 1934*

(Amendment No. 3)

 

 

Silence Therapeutics plc

(Name of Issuer)

Ordinary Shares, nominal value £0.05 per share

(Title of Class of Securities)

82686Q101**

(CUSIP Number)

September 30, 2024

(Date of Event Which Requires Filing of this Statement)

 

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

 

*

The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

**

This CUSIP number applies to the Issuer’s American Depositary Shares, each representing three ordinary shares of the Issuer.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

 

 

CUSIP No. 82686Q101

 

1   

NAMES OF REPORTING PERSONS

 

Invus Public Equities, L.P.

2   

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐  (b) ☐

 

3   

SEC USE ONLY

 

4   

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Bermuda

NUMBER OF

SHARES

BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

    5   

SOLE VOTING POWER

 

7,438,857*

   6   

SHARED VOTING POWER

 

0

   7   

SOLE DISPOSITIVE POWER

 

7,438,857*

   8   

SHARED DISPOSITIVE POWER

 

0

9   

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

7,438,857*

10   

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐

11   

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

5.3%

12   

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

PN

 

*

Invus Public Equities, L.P. holds an aggregate of 2,479,619 American Depositary Shares (“ADSs”), each of which ADS represents three ordinary shares, nominal value £0.05 per share, totaling 7,438,857 ordinary shares of the Issuer.

 

2

CUSIP No. 82686Q101

 

1   

NAMES OF REPORTING PERSONS

 

Invus Public Equities Advisors, LLC

2   

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐  (b) ☐

 

3   

SEC USE ONLY

 

4   

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware

NUMBER OF

SHARES

BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

    5   

SOLE VOTING POWER

 

7,438,857*

   6   

SHARED VOTING POWER

 

0

   7   

SOLE DISPOSITIVE POWER

 

7,438,857*

   8   

SHARED DISPOSITIVE POWER

 

0

9   

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

7,438,857*

10   

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐

11   

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

5.3%

12   

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO

 

*

Invus Public Equities, L.P. holds an aggregate of 2,479,619 American Depositary Shares (“ADSs”), each of which ADS represents three ordinary shares, nominal value £0.05 per share, totaling 7,438,857 ordinary shares of the Issuer.

 

3

CUSIP No. 82686Q101

 

1   

NAMES OF REPORTING PERSONS

 

Invus Global Management, LLC

2   

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐   ;(b) ☐

 

3   

SEC USE ONLY

 

4   

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware

NUMBER OF

SHARES

BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

    5   

SOLE VOTING POWER

 

7,438,857*

   6   

SHARED VOTING POWER

 

0

   7   

SOLE DISPOSITIVE POWER

 

7,438,857*

   8   

SHARED DISPOSITIVE POWER

 

0

9   

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

7,438,857*

10   

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐

11   

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

5.3%

12   

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO

 

*

Invus Public Equities, L.P. holds an aggregate of 2,479,619 American Depositary Shares (“ADSs”), each of which ADS represents three ordinary shares, nominal value £0.05 per share, totaling 7,438,857 ordinary shares of the Issuer.

 

4

CUSIP No. 82686Q101

 

1   

NAMES OF REPORTING PERSONS

 

Siren, L.L.C.

2   

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐  (b) ☐

 

3   

SEC USE ONLY

 

4   

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware

NUMBER OF

SHARES

BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

    5   

SOLE VOTING POWER

 

7,438,857*

   6   

SHARED VOTING POWER

 

0

   7   

SOLE DISPOSITIVE POWER

 

7,438,857*

   8   

SHARED DISPOSITIVE POWER

 

0

9   

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

7,438,857*

10   

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐

11   

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

5.3%

12   

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO

 

*

Invus Public Equities, L.P. holds an aggregate of 2,479,619 American Depositary Shares (“ADSs”), each of which ADS represents three ordinary shares, nominal value £0.05 per share, totaling 7,438,857 ordinary shares of the Issuer.

 

5

CUSIP No. 82686Q101

 

1   

NAMES OF REPORTING PERSONS

 

Avicenna Life Sci Master Fund LP

2   

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐  (b) ☐

 

3   

SEC USE ONLY

 

4   

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Cayman Islands

NUMBER OF

SHARES

BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

    5   

SOLE VOTING POWER

 

1,056,453 *

   6   

SHARED VOTING POWER

 

0

   7   

SOLE DISPOSITIVE POWER

 

1,056,453*

   8   

SHARED DISPOSITIVE POWER

 

0

9   

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,056,453*

10   

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐

11   

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

0.8%

12   

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

PN

 

*

Avicenna Life Sci Master Fund LP holds an aggregate of 352,151 American Depositary Shares (“ADSs”), each of which ADS represents three ordinary shares, nominal value £0.05 per share, totaling 1,056,453 ordinary shares of the Issuer.

 

6

CUSIP No. 82686Q101

 

1   

NAMES OF REPORTING PERSONS

 

Avicenna Life Sci Master GP LLC

2   

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐  (b) ☐

 

3   

SEC USE ONLY

 

4   

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware

NUMBER OF

SHARES

BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

    5   

SOLE VOTING POWER

 

1,056,453*

   6   

SHARED VOTING POWER

 

0

   7   

SOLE DISPOSITIVE POWER

 

1,056,453*

   8   

SHARED DISPOSITIVE POWER

 

0

9   

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,056,453*

10   

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐

11   

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

0.8%

12   

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO

 

*

Avicenna Life Sci Master Fund LP holds an aggregate of 352,151 American Depositary Shares (“ADSs”), each of which ADS represents three ordinary shares, nominal value £0.05 per share, totaling 1,056,453 ordinary shares of the Issuer.

 

7

CUSIP No. 82686Q101

 

1   

NAMES OF REPORTING PERSONS

 

Ulys, L.L.C.

2   

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐  (b) ☐

 

3   

SEC USE ONLY

 

4   

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware

NUMBER OF

SHARES BENEFICIALLY 

OWNED BY EACH REPORTING PERSON

WITH

    5   

SOLE VOTING POWER

 

1,056,453*

   6   

SHARED VOTING POWER

 

0

   7   

SOLE DISPOSITIVE POWER

 

1,056,453*

   8   

SHARED DISPOSITIVE POWER

 

0

9   

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,056,453*

10   

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐

11   

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

0.8%

12   

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO

 

*

Avicenna Life Sci Master Fund LP holds an aggregate of 352,151 American Depositary Shares (“ADSs”), each of which ADS represents three ordinary shares, nominal value £0.05 per share, totaling 1,056,453 ordinary shares of the Issuer.

 

8

CUSIP No. 82686Q101

 

1   

NAMES OF REPORTING PERSONS

 

Raymond Debbane

2   

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐  (b) ☐

 

3   

SEC USE ONLY

 

4   

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Panama

NUMBER OF

SHARES

BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

    5   

SOLE VOTING POWER

 

8,495,310*

   6   

SHARED VOTING POWER

 

0

   7   

SOLE DISPOSITIVE POWER

 

8,495,310*

   8   

SHARED DISPOSITIVE POWER

 

0

9   

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

8,495,310*

10   

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐

11   

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

6.1%

12   

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

IN

 

*

Invus Public Equities, L.P. holds an aggregate of 2,479,619 American Depositary Shares (“ADSs”) and Avicenna Life Sci Master Fund LP holds an aggregate of 352,151 ADSs, each of which ADS represents three ordinary shares, nominal value £0.05 per share, totaling 8,495,310 ordinary shares of the Issuer.

 

9

Item 1(a).

Name of Issuer:

Silence Therapeutics plc (the “Issuer”)

 

Item 1(b).

Address of Issuer’s Principal Executive Offices:

72 Hammersmith Road, London W14 8TH

 

Item 2(a).

Name of Person Filing:

 

Item 2(b).

Address of Principal Business Office or, if none, Residence:

 

Item 2(c).

Citizenship:

(i) Invus Public Equities, L.P. (“Invus Public Equities”)

750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Bermuda limited partnership

(ii) Invus Public Equities Advisors, LLC (“Invus PE Advisors”)

750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Delaware limited liability company

(iii) Invus Global Management, LLC (“Global Management”)

750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Delaware limited liability company

(iv) Siren, L.L.C. (“Siren”)

c/o The Invus Group, LLC, 750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Delaware limited liability company

(v) Avicenna Life Sci Master Fund LP (“Avicenna Fund”)

750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Cayman Islands limited partnership

(vi) Avicenna Life Sci Master GP LLC (“Avicenna GP”)

750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Delaware limited liability company

(vii) Ulys, L.L.C. (“Ulys”)

750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Delaware limited liability company

(viii) Mr. Raymond Debbane

750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Panama

The foregoing persons are hereinafter sometimes collectively referred to as the “Reporting Persons.”

 

Item 2(d).

Title of Class of Securities:

Ordinary Shares, nominal value £0.05 per share (the “Shares”)

 

10

Item 2(e).

CUSIP Number:

The CUSIP Number is 82686Q101. This CUSIP applies to the American Depositary Shares, evidenced by American Depositary Receipts, each representing three Shares. No CUSIP has been assigned to the Shares.

 

Item 3.

If This Statement Is Filed Pursuant to Sections 240.13d-1(b) or 240.13d-2(b) or (c), Check Whether the Person Filing Is a(n):

This Item 3 is not applicable.

 

Item 4.

Ownership.

(a) Amount beneficially owned:

As of September 30, 2024, Invus Public Equities beneficially held 7,438,857 Shares represented by an aggregate of 2,479,619 American Depositary Shares directly held by Invus Public Equities and Avicenna Fund beneficially held 1,056,453 Shares represented by an aggregate of 352,151 American Depositary Shares directly held by Avicenna. Invus PE Advisors, as the general partner of Invus Public Equities, controls Invus Public Equities and, accordingly, may be deemed to beneficially own the Shares directly held by Invus Public Equities. Global Management, as the managing member of Invus PE Advisors, controls Invus PE Advisors and, accordingly, may be deemed to beneficially own the Shares that Invus PE Advisors may be deemed to beneficially own. Siren, as the managing member of Global Management, controls Global Management and, accordingly, may be deemed to beneficially own the Shares that Global Management may be deemed to beneficially own. Avicenna GP, as the general partner of Avicenna Fund, controls Avicenna Fund and, accordingly, may be deemed to beneficially own the Shares beneficially held by Avicenna Fund. Ulys, as the managing member of Avicenna GP, controls Avicenna GP and, accordingly, may be deemed to beneficially own the Shares that Avicenna GP may be deemed to beneficially own. Mr. Raymond Debbane, as the managing member of Siren and Ulys, controls Siren and Ulys and, accordingly, may be deemed to beneficially own the Shares that Siren and Ulys may be deemed to beneficially own.

(b) Percent of class:

As of September 30, 2024, each of the Reporting Persons may be deemed to be the beneficial owner of the percentage of Shares listed on such Reporting Person’s cover page. Calculations of the percentage of Shares beneficially owned are based on 140,393,470 Shares outstanding as of June 30, 2024 based on information set forth in the Issuer’s Registration Statement on Form F-3 filed with the Securities and Exchange Commission on October 22, 2024.

(c) Number of shares as to which each Reporting Person has:

 

  (i)

Sole power to vote or to direct the vote:

See each cover page hereof.

 

  (ii)

Shared power to vote or to direct the vote:

See each cover page hereof.

 

  (iii)

Sole power to dispose or to direct the disposition of:

See each cover page hereof.

 

  (iv)

Shared power to dispose or to direct the disposition of:

See each cover page hereof.

 

Item 5.

Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ☐.

 

11

Item 6.

Ownership of More Than Five Percent on Behalf of Another Person.

This Item 6 is not applicable.

 

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company.

This Item 7 is not applicable.

 

Item 8.

Identification and Classification of Members of the Group.

This Item 8 is not applicable.

 

Item 9.

Notice of Dissolution of Group.

This Item 9 is not applicable.

 

Item 10.

Certification.

Each of the Reporting Persons hereby makes the following certification:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the Issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

 

12

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: November 12, 2024

 

INVUS PUBLIC EQUITIES, L.P.
By:   INVUS PUBLIC EQUITIES ADVISORS,
  LLC, its general partner
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   President
INVUS PUBLIC EQUITIES ADVISORS, LLC
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   President
INVUS GLOBAL MANAGEMENT, LLC
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   President
SIREN, L.L.C.
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   President
AVICENNA LIFE SCI MASTER FUND LP
By:   AVICENNA LIFE SCI MASTER GP LLC, its general partner
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   Chief Executive Officer
AVICENNA LIFE SCI MASTER GP LLC
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   Chief Executive Officer
ULYS, L.L.C.
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   President

MR. RAYMOND DEBBANE
By:   /s/ Raymond Debbane

EXHIBIT INDEX

 

Exhibit
Number

   

Title

1.    Joint Filing Agreement