Sec Form 3 Filing - Cacace Angela M @ ARVINAS, INC. - 2024-06-17

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Cacace Angela M 2. Issuer Name and Ticker or Trading Symbol ARVINAS, INC. [ ARVN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Scientific Officer (Last) (First) (Middle) C/O ARVINAS, INC., 5 SCIENCE PARK, 395 WINCHESTER AVE. 3. Date of Earliest Transaction (MM/DD/YY) 06/17/2024 (Street) NEW HAVEN, CT06511 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 8,437 ( 1 ) D Common Stock 15,835 ( 2 ) D Common Stock 11,585 ( 3 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (right to buy) $ 47 ( 4 ) 02/22/2034 Common Stock 23,425 D Stock Option (right to buy) $ 34.37 ( 5 ) 02/21/2033 Common Stock 38,350 D Stock Option (right to buy) $ 64.19 ( 6 ) 02/22/2032 Common Stock 52,400 D Stock Option (right to buy) $ 78.3 ( 7 ) 02/25/2031 Common Stock 37,000 D Stock Option (right to buy) $ 47.38 ( 8 ) 02/26/2030 Common Stock 26,667 D Stock Option (right to buy) $ 19.36 ( 9 ) 02/28/2029 Common Stock 20,470 D Stock Option (right to buy) $ 16 ( 10 ) 09/25/2028 Common Stock 33,654 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Cacace Angela M C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN, CT06511 Chief Scientific Officer Signatures /s/ Jared Freedberg, as attorney-in-fact for Angela M. Cacace 06/18/2024 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Includes 919 shares of common stock of the issuer previously purchased by the reporting person under the issuer's 2018 Employee Stock Purchase Plan. ( 2 )The restricted stock units (each, an "RSU") were granted by the issuer on February 23, 2024, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the issuer's common stock upon settlement for no consideration. The RSUs vest over two years: 1/2 of the shares underlying the award shall vest on February 23, 2025, with the remainder of the shares vesting on February 23, 2026. ( 3 )The RSUs were granted by the Issuer on February 22, 2023, pursuant to the Plan and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs vest over four years: 1/4 of the shares underlying the award vested on February 22, 2024, with the remainder of the shares vesting in equal annual installments thereafter through February 23, 2027. The RSU amount reflects that 1,190 shares were sold to pay for taxes following the February 22, 2024 vesting. ( 4 )The option was granted by the Issuer on February 23, 2024, pursuant to the Plan. The shares underlying the option vest over two years: 1/2 of the shares underlying the award shall vest on February 23, 2025, with the remainder of the shares vesting on February 23, 2026. ( 5 )The option was granted by the Issuer on February 22, 2023, pursuant to the Plan. The shares underlying the option vest over four years: 1/4 of the shares underlying the award vested on February 22, 2024, with the remainder of the shares vesting in equal monthly installments following February 22, 2024 through February 23, 2027. ( 6 )The option was granted by the Issuer on February 23, 2022, pursuant to the Plan. The shares underlying the option vest over four years: 1/4 of the shares underlying the award vested on February 23, 2023, with the remainder of the shares vesting in equal monthly installments following February 23, 2023 through February 23, 2026. ( 7 )The option was granted by the Issuer on February 26, 2021, pursuant to the Plan. The shares underlying the option vest over four years: 1/4 of the shares underlying the award vested on February 26, 2022, with the remainder of the shares vesting in equal monthly installments following February 23, 2022 through February 23, 2025. ( 8 )The option was granted by the Issuer on February 27, 2020, pursuant to the Plan. The shares underlying the option vested over four years: 1/4 of the shares underlying the award vested on February 27, 2021 and the remainder of the shares vested in equal monthly installments following February 27, 2021 through February 27, 2024. ( 9 )The option was granted by the Issuer on March 1, 2019, pursuant to the Plan. The shares underlying the option vested over four years: 1/4 of the shares underlying the award vested on March 1, 2020 and the remainder of the shares vested in equal monthly installments following March 1, 2020 through March 1, 2023. ( 10 )The option was granted by the Issuer on September 26, 2018, pursuant to the Plan. The shares underlying the option vested over four years: 1/4 of the shares underlying the award vested on May 14, 2019 and the remainder of the shares vested in equal monthly installments following May 14, 2019 through May 14, 2022.

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