| 1 | DOMAIN PARTNERS IV LP
BLAIR JAMES C
DOVEY BRIAN H
TREU JESSE I
SCHOEMAKER KATHLEEN K
10% Owner | 2015-07-01 15:30:13 | 2,068,960
0 | 2,068,960 | Form 4 |
| 2 | Domain Partners VIII L.P.
BLAIR JAMES C
DOVEY BRIAN H
TREU JESSE I
SCHOEMAKER KATHLEEN K
VITULLO NICOLE
Halak Brian K
10% Owner | 2016-01-19 16:09:35 | 2,068,960
0 | 2,068,960 | Form 13G |
| 3 | Burns Thomas William
CHAIRMAN & CEO | 2025-09-24 18:52:52 | 150,705
1,452,039 | 1,602,744 | Form 4 |
| 4 | InterWest Management Partners IX LLC
InterWest Partners IX LP
GIANOS PHILIP T
Holmes W Stephen
ORONSKY ARNOLD L
CLEVELAND BRUCE A
Kjellson Nina S
NASR KHALED
Pepper Douglas A
10% Owner | 2017-02-14 12:24:55 | 1,035,445
0 | 1,035,445 | Form 13G |
| 5 | Meritech Capital Associates III L.L.C.
Meritech Capital Partners III LP
MERITECH CAPITAL AFFILIATES III L P
GORDON MICHAEL B
Ward Rob
Bischof George
10% Owner | 2018-02-14 17:25:15 | 862,947
0 | 862,947 | Form 13G |
| 6 | ORBIMED ADVISORS LLC
OrbiMed Capital GP III LLC
ISALY SAMUEL D
Director | 2018-02-13 16:39:14 | 836,500
0 | 836,500 | Form 13G |
| 7 | VERSANT VENTURES I LLC
LUBASH BARBARA N
ROBERTSON REBECCA B
Former 10 % owner | 2016-06-02 21:16:22 | 0
650,769 | 650,769 | Form 4 |
| 8 | HARRISON RICHARD L
CFO & Treasurer | 2017-01-13 17:04:26 | 48,701
206,000 | 254,701 | Form 4 |
| 9 | Calcaterra Chris M.
Chief Operating Officer | 2022-03-28 20:27:05 | 192,895
0 | 192,895 | Form 4 |
| 10 | Gilliam Joseph E
PRESIDENT & COO | 2025-11-20 19:56:01 | 92,366
0 | 92,366 | Form 4 |
| 11 | Navratil Tomas
CHIEF DEVELOPMENT OFFICER | 2025-09-24 18:53:20 | 75,907
0 | 75,907 | Form 4 |
| 12 | VERSANT VENTURES I LLC
VERSANT VENTURE CAPITAL I LP
VERSANT AFFILIATES FUND I-A LP
VERSANT AFFILIATES FUND I-B LP
VERSANT SIDE FUND I LP
ATWOOD BRIAN G
COLELLA SAMUEL D
JAFFE ROSS A MD
LINK WILLIAM J PHD
MILDER DONALD B
Former 10 % owner | 2017-02-14 15:38:25 | 71,428
0 | 71,428 | Form 13G |
| 13 | Hoffmeister David F
Director | 2025-06-13 19:43:41 | 31,918
38,176 | 70,094 | Form 4 |
| 14 | DOMAIN ASSOCIATES
BLAIR JAMES C
DOVEY BRIAN H
TREU JESSE I
SCHOEMAKER KATHLEEN K
VITULLO NICOLE
Halak Brian K
Kamdar Kim P.
10% Owner | 2015-06-24 16:59:34 | 63,200
0 | 63,200 | Form 3 |
| 15 | Foley Mark J
Director | 2025-06-02 16:44:12 | 60,370
0 | 60,370 | Form 4 |
| 16 | LINK WILLIAM J PHD
Director | 2021-06-07 19:05:31 | 17,821
40,479 | 58,300 | Form 4 |
| 17 | MADERA PAUL S
Director
10% Owner | 2015-06-30 18:09:49 | 0
54,177 | 54,177 | Form 4 |
| 18 | WEISNER AIMEE S
Director | 2025-06-02 16:42:09 | 22,312
30,525 | 52,837 | Form 4 |
| 19 | Thurman Alex R.
SVP & CHIEF FINANCIAL OFFICER | 2025-11-26 17:00:13 | 50,488
0 | 50,488 | Form 4 |
| 20 | Kliman Gilbert H
Director | 2025-12-11 16:20:43 | 44,905
0 | 44,905 | Form 4 |
| 21 | Stapley Marc
Director | 2025-06-02 16:42:48 | 39,871
0 | 39,871 | Form 4 |
| 22 | BERGHEIM OLAV
Director | 2015-07-24 17:23:26 | 25,000
0 | 25,000 | Form 4 |
| 23 | Torres Denice
Director | 2025-06-02 16:41:20 | 24,860
0 | 24,860 | Form 4 |
| 24 | WEN LEANA
Director | 2025-06-02 16:39:57 | 23,965
0 | 23,965 | Form 4 |
| 25 | DP IV ASSOCIATES LP
BLAIR JAMES C
DOVEY BRIAN H
TREU JESSE I
SCHOEMAKER KATHLEEN K
10% Owner | 2015-07-01 15:26:15 | 14,041
0 | 14,041 | Form 4 |
| 26 | DP VIII Associates L.P.
BLAIR JAMES C
DOVEY BRIAN H
TREU JESSE I
SCHOEMAKER KATHLEEN K
VITULLO NICOLE
Halak Brian K
10% Owner | 2015-07-01 15:33:53 | 6,501
0 | 6,501 | Form 4 |
| 27 | MORE ROBERT J
Director | 2015-06-30 18:11:33 | 5,000
0 | 5,000 | Form 4 |
| 28 | SILVERSTEIN JONATHAN
Director | 2018-03-06 19:41:46 | 0
0 | 0 | Form 4 |
| 29 | ORBIMED ADVISORS LLC
OrbiMed Capital GP III LLC
Director | 2018-03-06 19:36:22 | 0
0 | 0 | Form 4 |
| 30 | MONTREUX EQUITY PARTNERS IV LP
Montreux Equity Management IV LLC
Montreux IV Associates LLC
10% Owner | 2017-01-31 16:45:59 | 0
0 | 0 | Form 13G |
| 31 | Frazier Healthcare V LP
FHM V LLC
Every Nathan R
FRAZIER ALAN D
Naini Nader J
Heron Patrick J
Topper James N
FHM V LP
10% Owner | 2017-02-14 16:58:53 | 0
0 | 0 | Form 13G |